| | Day | Time | | Opponent | Score | | Record |
| November |
| | 4 | 4:00PM | @ | St. Mary of the Woods | W-57-39 | | 1-0 |
| | IU Southeast is now 1-0 (0-0 KAIC) - FWO/Courtyard Marriott - First Round |
| | 5 | 6:00PM | @ | University of Saint Francis | L-60-91 | | 1-1 |
| | FWO/Courtyard Marriott Championship Game |
| | 8 | 7:30PM | vs. | St. Andrews College | L-78-80 (OT) | | 1-2 |
| | IU Southeast is now 1-2 (0-0 KIAC) this season. |
| * | 12 | 4:00PM | @ | Mid-Continent College | W-71-36 | | 2-2 1-0 |
| | Coach Kevin Brown |
| | 15 | 7:00PM | @ | Oakland City University | L-55-59 | | 2-3 |
| | Make-up game for originally scheduled game 11/15/05 |
| | 18 | 6:00PM | vs. | Transylvania University | W-62-50 | | 3-3 |
| | 19 | 4:00PM | vs. | University of the South | L-49-77 | | 3-4 |
| | 29 | 7:30PM | vs. | Transylvania University | W-64-50 | | 4-4 |
| December |
| | 3 | 1:00PM | vs. | Central Babtist College | W-77-62 | | 5-4 |
| | Bethel College (Tenn.) Classic |
| | 9 | 7:00PM | vs. | Taylor University-Ft. Wayne | W-69-49 | | 6-4 |
| | 13 | 7:00PM | vs. | St. Mary of the Woods | W-69-46 | | 7-4 |
| * | 17 | 3:00PM | @ | Alice Lloyd | W-76-67 | | 8-4 2-0 |
| January |
| * | 7 | 6:00PM | @ | Spalding University | L-49-59 | | 8-5 2-1 |
| * | 10 | 8:30PM | vs. | Asbury | W-75-52 | | 9-5 3-1 |
| | 12 | 7:00PM | @ | St. Mary of the Woods | W-77-46 | | 10-5 |
| * | 14 | 5:00PM | vs. | Berea | L-85-97 | | 10-6 3-2 |
| * | 17 | 8:00PM | @ | Asbury | W-64-57 | | 11-6 4-2 |
| * | 19 | 7:30PM | vs. | Midway | L-55-63 | | 11-7 4-3 |
| | 21 | 1:00PM | @ | Kentucky Christian College | L-57-77 | | 11-8 |
| * | 28 | 2:00PM | @ | Bethel College | L-66-67 | | 11-9 4-4 |
| February |
| * | 2 | 7:00PM | vs. | Spalding University | W-64-50 | | 12-9 5-4 |
| * | 4 | 6:00PM | @ | Berea | L-79-80 | | 12-10 5-5 |
| * | 7 | 5:30PM | vs. | Mid-Continent College | W-91-33 | | 13-10 6-5 |
| * | 9 | 7:00PM | @ | Midway | L-61-62 | | 13-11 6-6 |
| | Amy Klein's ('99-'03) Jersey Retirement Ceremony at Half-time. |
| * | 11 | 3:00PM | vs. | Alice Lloyd | W-90-58 | | 14-11 7-6 |
| * | 16 | 7:30PM | vs. | Bethel College | L-77-89 | | 14-12 7-7 |
| | Bethel wins 15th straight and improves to 14-0 in conference action |
| * | 18 | 4:00PM | @ | SLCOP | W-81-46 | | 15-12 8-7 |
| | 22 | 6:00PM | vs. | Alice Lloyd | W-85-66 | | 16-12 |
| | First Round of KIAC Tournament #4 - IUS versus #5 - ALC |
| | 24 | 4:00PM | vs. | Berea | L-57-77 | | 16-13 |
| | Semifinal #2 of KIAC Women's Basketball Tournament |
