| February |
| | 24 | 1:00PM | Ohio Dominican College | @ | Spalding University | 14-1 |  |
| | 27 | | Spalding University | @ | Campbellsville University | 8-8 | |
| | | 2:00PM | Spalding University | @ | Campbellsville University | 1-9 | |
| March |
| * | 2 | | Alice Lloyd | @ | IU Southeast | 0-10 | (5) |
| | | 12:30PM | Midway | @ | St. Catherine | RAIN | |
| * | | Game 2 | Alice Lloyd | @ | IU Southeast | 0-11 | (5) |
| | First Game in IU Southeast Softball History |
| | 3 | 10:00AM | Calumet College of St. Joseph | @ | IU Southeast | 7-10 | |
| | Grenadier Classic at IU Southeast - March 3-4 |
| | | 12:00PM | Concord College | @ | IU Southeast | 1-0 | (6) |
| | Grenadier Classic at IU Southeast - March 3-4 |
| * | | 1:00PM | Alice Lloyd | @ | Spalding University | 1-10 | |
| * | | Game 2 | Alice Lloyd | @ | Spalding University | 0-12 | |
| | 4 | 12:00PM | Concord College | @ | IU Southeast | 1-12 | (5) |
| | Grenadier Classic at IU Southeast - March 3-4 |
| | | 2:00PM | Union College | @ | Spalding University | 5-2 | |
| | | 4:00PM | Calumet College of St. Joseph | @ | IU Southeast | 3-8 | |
| | Grenadier Classic at IU Southeast - March 3-4 |
| | | Game 2 | Union College | @ | Spalding University | 9-1 | |
| | 6 | 1:00PM | Pikeville College | @ | Alice Lloyd | 9-0 | |
| | | Game 2 | Pikeville College | @ | Alice Lloyd | 17-0 | |
| | | 6:00PM | Hanover College | @ | Spalding University | 0-5 | |
| | | Game 2 | Hanover College | @ | Spalding University | 3-11 | (6) |
| | 8 | Game 2 | Midway | @ | Georgetown College | 4-6 | |
| | | 2:00PM | Midway | @ | Georgetown College | 0-6 | |
| | | 3:00PM | Spalding University | @ | Transylvania University | 3-4 | |
| | | Game 2 | Spalding University | @ | Transylvania University | 4-12 | (5) |
| | 10 | | Spalding University | @ | Shawnee State University | 0-4 | |
| | | 1:00PM | Oakland City University | @ | Berea | 12-0 | |
| | | 2:00PM | Spalding University | @ | Shawnee State University | 2-3 | |
| | | Game 2 | Oakland City University | @ | Berea | 19-1 | |
| | | 4:00PM | Brescia | @ | Mid-Continent College | 4-0 | |
| | | Game 2 | Brescia | @ | Mid-Continent College | 1-8 | |
| | 11 | 2:00PM | Oakland City University | @ | Spalding University | 11-7 | |
| | | Game 2 | Oakland City University | @ | Spalding University | 2-6 | |
| | Walk Off Grand Slamd by Senior Rachel Reliford |
| | 13 | 5:30PM | Union College | @ | Berea | 8-0 | (5) |
| * | | 6:00PM | IU Southeast | @ | Spalding University | 2-10 | (6) |
| | | Game 2 | Union College | @ | Berea | 11-3 | (6) |
| * | | Game 2 | IU Southeast | @ | Spalding University | 4-5 | (8) |
| | 15 | 2:00PM | Spalding University | @ | Georgetown College | RAIN | |
| | 16 | 2:00PM | IU Southeast | @ | King College | RAIN | |
| | | Game 2 | IU Southeast | @ | King College | RAIN | |
| | 17 | 12:00PM | Berea | @ | Oakland City University | 2-6 | |
| | | 1:00PM | Spalding University | @ | Union College | 2-3 | |
| | | 1:00PM | Spalding University | @ | Union College | 0-8 | |
| | | 2:00PM | IU Southeast | @ | Montreat College | 2-9 | |
| | | Game 2 | Berea | @ | Oakland City University | 5-15 | |
| | | 4:00PM | IU Southeast | @ | Montreat College | 4-12 | |
| * | 18 | 12:00PM | Berea | @ | Brescia | 4-12 | |
| | | 1:00PM | IU Southeast | @ | Milligan College | 1-6 | |
| * | | Game 2 | Berea | @ | Brescia | 0-13 | |
| | | Game 2 | IU Southeast | @ | Milligan College | 0-8 | (5) |
| * | 20 | Game 2 | Spalding University | @ | Midway | 10-3 | |
| | | 1:00PM | Union University | @ | Brescia | RAIN | |
| | | Game 2 | Union University | @ | Brescia | RAIN | |
| * | | 5:00PM | IU Southeast | @ | Berea | 14-1 | |
| * | | 6:00PM | Spalding University | @ | Midway | 14-0 | |
| * | | 7:00PM | IU Southeast | @ | Berea | 11-3 | |
| | 21 | 2:00PM | Brescia | @ | Georgetown College | 5-3 | |
| | | 3:00PM | Alice Lloyd | @ | Union College | 0-8 | |
| | | Game 2 | Alice Lloyd | @ | Union College | 1-10 | |
| | | 4:00PM | Brescia | @ | Georgetown College | 1-0 | |
| | | Game 2 | Lindsey Wilson | @ | Spalding University | 6-1 | |
| | | 7:00PM | Lindsey Wilson | @ | Spalding University | 5-9 | |
| | 22 | 3:00PM | Spalding University | @ | Hanover College | RAIN | |
| | | 3:00PM | Spalding University | @ | Hanover College | RAIN | |
| | 23 | 10:40AM | Alice Lloyd | @ | Pikeville College | 0-9 | |
| | | 1:00PM | Midway | @ | Union College | 0-8 | |
| | | Game 2 | Midway | @ | Union College | 2-5 | |
| | | 2:00PM | Olivet Nazarene University | @ | IU Southeast | RAIN | |
| | | Game 2 | Olivet Nazarene University | @ | IU Southeast | RAIN | |
| * | | 5:00PM | Brescia | @ | Berea | 8-1 | |
| | | Game 2 | Alice Lloyd | @ | Pikeville College | 1-11 | |
| * | | Game 2 | Brescia | @ | Berea | 7-0 | |
| * | 24 | 7:59AM | Brescia | @ | Alice Lloyd | 9-0 | |
| * | | Game 2 | Brescia | @ | Alice Lloyd | 17-0 | |
| * | | 1:00PM | Berea | @ | Spalding University | 7-1 | |
| * | | Game 2 | IU Southeast | @ | Midway | 3-4 | |
| * | | 3:00PM | IU Southeast | @ | Midway | 4-8 | |
| * | | 3:00PM | Berea | @ | Spalding University | 3-6 | |
| | 27 | Game 2 | St. Catherine | @ | Midway | 2-11 | |
| | | 4:30PM | St. Catherine | @ | Midway | 8-14 | |
| * | | 5:00PM | Brescia | @ | Spalding University | 6-4 | |
| * | | 8:00PM | Brescia | @ | Spalding University | 1-12 | |
| | 28 | 4:00PM | Lindsey Wilson | @ | Brescia | RAIN | |
| | | Game 2 | Lindsey Wilson | @ | Brescia | RAIN | |
| * | 29 | 5:30PM | Berea | @ | Alice Lloyd | 8-4 | |
| * | | Game 2 | Berea | @ | Alice Lloyd | 6-5 | |
| * | | 6:00PM | Midway | @ | Spalding University | 1-2 | |
| * | | 8:00PM | Midway | @ | Spalding University | 4-5 | |
| | 30 | 11:00AM | IU Southeast | @ | Trinity Christian College | 4-9 | |
| | ONU Invitational Tournament (IL) |
| | | 1:00PM | IU Southeast | vs. | Wisconsin-Oshkosh | 0-1 | |
| | ONU Invitational Tournament (IL) |
| | | 3:30PM | Spalding University | @ | McKendree College | 0-2 | |
| | | 5:30PM | Spalding University | @ | McKendree College | RAIN | |
| * | 31 | Game 2 | Brescia | @ | Midway | 2-3 | |
| | | 9:00AM | IU Southeast | @ | Olivet Nazarene University | 5-9 | |
| | ONU Invitational Tournament (Ill.) |
| | | 11:00AM | Spalding University | @ | University of Illinois at Springfield | 1-7 | |
| | McKendree College Invitational |
| | | 1:00PM | Spalding University | vs. | Ohio Dominican College | 0-8 | |
| | McKendree College Invitational |
| * | | 1:00PM | Brescia | @ | Midway | 6-0 | |
| | | 1:00PM | IU Southeast | @ | Wisconsin-Oshkosh | 0-3 | |
| | ONU Invitational Tournament Consolation Game |
| April |
| | 1 | 1:00PM | Franklin College | @ | Spalding University | 4-8 | |
| | | Game 2 | Franklin College | @ | Spalding University | 4-8 | |
| * | 2 | 4:00PM | Alice Lloyd | @ | Midway | 0-8 | |
| * | | Game 2 | Alice Lloyd | @ | Midway | 2-11 | |
| | 3 | 3:00PM | Campbellsville University | @ | Brescia | 4-0 | |
| | | 6:00PM | Kentucky State University | @ | Spalding University | RAIN | |
| | | Game 2 | Kentucky State University | @ | Spalding University | RAIN | |
| | 4 | Game 2 | Mountain State | @ | Midway | 6-8 | |
| | | 2:00PM | Georgetown College | @ | IU Southeast | 1-2 | |
| | | 4:00PM | Georgetown College | @ | IU Southeast | 6-2 | |
| | | 4:00PM | Spalding University | @ | Lindsey Wilson | 0-8 | |
| | | 5:00PM | Spalding University | @ | Lindsey Wilson | 1-5 | |
| | | 5:00PM | Mountain State | @ | Midway | 1-2 | (8) |
| | 5 | 9:24AM | Kentucky State University | @ | Alice Lloyd | 10-0 | |
| * | | 2:00PM | Midway | @ | IU Southeast | 1-9 | |
| | | Game 2 | Kentucky State University | @ | Alice Lloyd | 10-0 | |
| | | 3:00PM | St. Mary's | @ | Brescia | 8-9 | |
| * | | 4:00PM | Midway | @ | IU Southeast | 2-10 | (6) |
| | | Game 2 | St. Mary's | @ | Brescia | 8-3 | |
| * | 6 | 3:00PM | Brescia | @ | IU Southeast | 1-10 | |
| * | | Game 2 | Brescia | @ | IU Southeast | 1-6 | |
| | 9 | 3:00PM | Union College | @ | Alice Lloyd | 13-0 | |
| | | Game 2 | Union College | @ | Alice Lloyd | 10-2 | |
| | | 6:00PM | Campbellsville University | @ | Spalding University | 8-0 | |
| | | 8:00PM | Campbellsville University | @ | Spalding University | 12-2 | |
| | 10 | Game 2 | Brescia | @ | Oakland City University | 3-0 | |
| | | 3:00PM | Brescia | @ | Oakland City University | 0-10 | |
| | | 3:00PM | Midway | @ | Kentucky State University | 4-6 | (9) |
| | | Game 2 | Midway | @ | Kentucky State University | 13-10 | |
| * | | 5:30PM | Spalding University | @ | Berea | 17-5 | |
| * | | Game 2 | Spalding University | @ | Berea | 10-1 | |
| | 11 | 3:00PM | Marian College | @ | IU Southeast | RAIN | |
| | | 3:00PM | Midway | @ | Lindsey Wilson | RAIN | |
| | | 3:00PM | Midway | @ | Lindsey Wilson | RAIN | |
| | | 5:00PM | Marian College | @ | IU Southeast | RAIN | |
| | 12 | Game 2 | Kentucky State University | @ | Midway | RAIN | |
| | | 4:00PM | Kentucky State University | @ | Midway | RAIN | |
| | | 4:30PM | Spalding University | @ | Oakland City University | RAIN | |
| | | Game 2 | Spalding University | @ | Oakland City University | RAIN | |
| * | 14 | Game 2 | Midway | @ | Brescia | RAIN | |
| * | | 1:00PM | Midway | @ | Brescia | RAIN | |
| * | 15 | 12:00PM | Alice Lloyd | @ | Brescia | RAIN | |
| * | | Game 2 | Alice Lloyd | @ | Brescia | RAIN | |
| | | Game 2 | IU Southeast | @ | Purdue University-North Central | 1-6 | |
| | | 5:00PM | IU Southeast | @ | Purdue University-North Central | 1-2 | |
| | 16 | 3:00PM | Brescia | @ | Oakland City University | 10-2 | |
| | | Game 2 | Brescia | @ | Oakland City University | 3-0 | |
| | 17 | 3:00PM | University of the Cumberlands | @ | Brescia | 4-0 | |
| | | 4:00PM | Spalding University | @ | Kentucky State University | 10-0 | (5) |
| | | Game 2 | Spalding University | @ | Kentucky State University | 3-5 | (5) |
| * | | 5:00PM | Midway | @ | Berea | 11-4 | |
| * | | Game 2 | Midway | @ | Berea | 10-0 | (5) |
| | | Game 2 | University of the Cumberlands | @ | Brescia | 6-5 | |
| | 19 | 3:00PM | Union College | @ | Midway | 16-5 | (5) |
| | | Game 2 | Oakland City University | @ | IU Southeast | 6-7 | |
| | | Game 2 | Union College | @ | Midway | 7-8 | |
| | | 5:00PM | Oakland City University | @ | IU Southeast | 2-6 | |
| * | 20 | 1:00PM | Midway | @ | Alice Lloyd | 11-1 | (5) |
| * | | Game 2 | Midway | @ | Alice Lloyd | 9-2 | |
| * | 21 | 11:00AM | Berea | @ | IU Southeast | 2-10 | |
| * | | 2:00PM | Alice Lloyd | @ | Brescia | 0-8 | |
| * | | Game 2 | Berea | @ | IU Southeast | 1-5 | |
| * | | Game 2 | Alice Lloyd | @ | Brescia | 0-15 | |
| * | 22 | 2:00PM | IU Southeast | @ | Brescia | 5-6 | |
| * | | Game 2 | Alice Lloyd | @ | Spalding University | 0-14 | (5) |
| * | | Game 2 | Alice Lloyd | @ | Spalding University | 0-19 | (5) |
| * | | Game 2 | IU Southeast | @ | Brescia | 0-9 | |
| | 23 | 3:00PM | Lindsey Wilson | @ | Midway | 6-0 | |
| | | 3:00PM | Lindsey Wilson | @ | Midway | 10-3 | |
| | | 3:00PM | Brescia | @ | Campbellsville University | 5-10 | |
| | | 3:00PM | Brescia | @ | Campbellsville University | 2-6 | |
| * | 24 | 2:00PM | Spalding University | @ | IU Southeast | 2-4 | |
| * | | Game 2 | Spalding University | @ | IU Southeast | 6-12 | |
| | | 4:30PM | Georgetown College | @ | Midway | 7-0 | (5) |
| | | 4:30PM | Georgetown College | @ | Midway | 3-2 | |
| * | | 5:30PM | Alice Lloyd | @ | Berea | 3-12 | |
| * | | Game 2 | Alice Lloyd | @ | Berea | 6-14 | |
| | 25 | 2:00PM | Spalding University | @ | Bellarmine University | 4-5 | |
| | | Game 2 | Spalding University | @ | Bellarmine University | 0-8 | (5) |
| * | 26 | Game 2 | Berea | @ | Midway | 4-8 | |
| * | | 6:00PM | Berea | @ | Midway | 0-8 | (6) |
| * | 27 | 1:00PM | IU Southeast | @ | Alice Lloyd | 14-0 | |
| * | | Game 2 | IU Southeast | @ | Alice Lloyd | 11-0 | |
| * | | 6:00PM | Spalding University | @ | Brescia | 3-1 | |
| * | | Game 2 | Spalding University | @ | Brescia | 2-8 | |
| | 28 | 10:00AM | IU Southeast | @ | Mountain State | 6-10 | |
| | | Game 2 | IU Southeast | @ | Mountain State | 3-6 | |
| | | 2:00PM | Berea | @ | Union College | 0-9 | |
| | | 3:00PM | IU Southeast | @ | Bluefield College | 15-4 | (5) |
| | | Game 2 | Berea | @ | Union College | 0-5 | |
| | | Game 2 | IU Southeast | @ | Bluefield College | 17-5 | (5) |
| | 29 | 2:00PM | IU Southeast | @ | UVA-Wise | 2-5 | |
| | | 4:00PM | IU Southeast | @ | UVA-Wise | 4-0 | |
| May |
| | 4 | 11:00AM | Berea | vs. | Midway | 1-9 | |
| | KIAC First Round at Midway, Kentucky |
| | | 1:00PM | Alice Lloyd | vs. | IU Southeast | 0-14 | (5) |
| | KIAC First Round at Midway, Kentucky (Game 2) |
| | | 3:00PM | Midway | vs. | Spalding University | 0-7 | |
| | KIAC Semifinals at Midway, Kentucky (Game 3) |
| | | 5:00PM | Brescia | vs. | IU Southeast | 1-1 | |
| | Brescia wihdrew from conference tournament after this game was rained out. |
| | 6 | 2:00PM | IU Southeast | vs. | Spalding University | 10-3 | |
| | KIAC Finals at New Albany, Indiana (Game 5) |
| | 9 | 10:00AM | Spalding University | vs. | Virginia Intermont College | 4-15 | |
| | Region XII First Round |
| | | 10:00AM | Milligan College | vs. | Brescia | 5-1 | |
| | NAIA Region XII Tournament - Losers' Bracket |
| | | 5:00PM | Spalding University | vs. | Milligan College | 3-12 | |
| | Region XII Loser Bracket |
| | | 7:00PM | Brescia | vs. | Milligan College | 0-11 | |
| | Region XII Loser Bracket |