| February |
| | 15 | 3:00PM | Martin Methodist | @ | Bethel College | 11-5 | |
| | | Game 2 | Martin Methodist | @ | Bethel College | 5-2 | |
| | 17 | 2:00PM | William Woods University | @ | Mid-Continent College | RAIN | |
| | | Game 2 | William Woods University | @ | Mid-Continent College | RAIN | |
| | | 3:00PM | Bethel College | @ | Freed-Hardeman | 0-2 | |
| | | Game 2 | Bethel College | @ | Freed-Hardeman | 8-2 | |
| | | 4:30PM | Concordia University | @ | Brescia | RAIN | |
| | | Game 2 | Concordia University | @ | Brescia | RAIN | |
| | 18 | 1:00PM | Spalding University | @ | Kentucky Wesleyan College | RAIN | |
| | Cancelled |
| | | Game 2 | Spalding University | @ | Kentucky Wesleyan College | RAIN | |
| | | 2:00PM | William Woods University | @ | Bethel College | RAIN | |
| | | Game 2 | William Woods University | @ | Bethel College | RAIN | |
| | 19 | 1:00PM | Concordia Illinois | @ | Spalding University | RAIN | |
| | v. Concordia University |
| | | Game 2 | Concordia Illinois | @ | Spalding University | RAIN | |
| | 21 | 2:00PM | Williams Baptist College | @ | Bethel College | 0-3 | |
| | | Game 2 | Williams Baptist College | @ | Bethel College | 5-4 | |
| | 22 | 2:00PM | Brescia | @ | Campbellsville University | 0-1 | |
| | second game--darkness |
| | 23 | 2:00PM | Lane College | @ | Bethel College | RAIN | |
| | | Game 2 | Lane College | @ | Bethel College | RAIN | |
| | 24 | 3:00PM | Kentucky Wesleyan College | @ | Brescia | 0-3 | |
| | | Game 2 | Kentucky Wesleyan College | @ | Brescia | 6-3 | |
| * | 25 | 1:00PM | Berea | @ | Spalding University | 6-10 | |
| * | | Game 2 | Berea | @ | Spalding University | 6-10 | |
| | | 2:00PM | Georgetown College | @ | Brescia | 11-3 | |
| | | Game 2 | Georgetown College | @ | Brescia | 13-1 | |
| | 27 | 3:00PM | Mid-Continent College | @ | Christian Brothers University | 2-8 | |
| | | Game 2 | Mid-Continent College | @ | Christian Brothers University | 7-6 | |
| | 28 | 5:00PM | Trevecca Nazarene University | @ | Brescia | 8-0 | |
| | | Game 2 | Trevecca Nazarene University | @ | Brescia | 20-5 | |
| | | 6:00PM | Union College | @ | Spalding University | 7-15 | (5) |
| | v. Union College |
| | | Game 2 | Union College | @ | Spalding University | 7-15 | |
| March |
| | 1 | 2:00PM | Alice Lloyd | @ | Union College | 0-8 | |
| | | Game 2 | Alice Lloyd | @ | Union College | 0-18 | |
| | | 3:00PM | Christian Brothers University | @ | Bethel College | 4-1 | |
| | | Game 2 | Christian Brothers University | @ | Bethel College | 3-4 | (8) |
| | | 3:00PM | Oakland City University | @ | Mid-Continent College | 0-3 | |
| | | Game 2 | Oakland City University | @ | Mid-Continent College | 5-0 | |
| | 3 | 11:00AM | Campbellsville University | @ | Brescia | 2-4 | |
| | BRESCIA UNIV. TOURNAMENT |
| | | 4:00PM | Marian College | @ | Brescia | 4-14 | |
| | BRESCIA UNIV. TOURNAMENT |
| * | | 6:00PM | Bethel College | @ | Spalding University | 2-3 | |
| * | | Game 2 | Bethel College | @ | Spalding University | 15-1 | |
| | 4 | 11:00AM | Oakland City University | @ | Brescia | 2-1 | |
| | BRESCIA UNIV. TOURNAMENT |
| * | | 12:00PM | Mid-Continent College | @ | Alice Lloyd | 13-1 | (5) |
| | | 12:00PM | Spalding University | @ | Georgetown College | 3-5 | |
| | | Game 2 | Spalding University | @ | Georgetown College | 6-9 | |
| * | | Game 2 | Mid-Continent College | @ | Alice Lloyd | 18-0 | (5) |
| | | 4:00PM | Kentucky Wesleyan College | @ | Brescia | 5-10 | |
| | BRESCIA UNIV. TOURNAMENT |
| | 5 | 1:00PM | Marian College | @ | Brescia | 3-5 | |
| | | Game 2 | Marian College | @ | Brescia | 9-1 | (5) |
| | | 1:00PM | Spalding University | @ | Union College | 6-5 | (8) |
| | | Game 2 | Spalding University | @ | Union College | 5-4 | |
| | 6 | 5:30PM | Union College | @ | Berea | 16-14 | |
| | | Game 2 | Union College | @ | Berea | 2-9 | |
| | 7 | 3:00PM | Mid-Continent College | @ | Freed-Hardeman | 0-3 | |
| | | 5:00PM | Brescia | @ | Centre College | 2-4 | |
| | | Game 2 | Brescia | @ | Centre College | 6-5 | |
| | | Game 2 | Mid-Continent College | @ | Freed-Hardeman | 0-7 | |
| | 10 | 11:00AM | Brescia | vs. | University of Mobile | 3-13 | (5) |
| | NFCA CLASSIC |
| | | 2:00PM | Mid-Continent College | @ | Lambuth University | 1-2 | |
| | Lambuth University Tournament |
| | | Game 2 | Mid-Continent College | @ | Lambuth University | 7-6 | |
| | | 5:00PM | Brescia | vs. | Trevecca Nazarene University | 0-8 | (5) |
| | NFCA CLASSIC |
| | | 7:00PM | Brescia | vs. | Oklahoma Christian University | 2-8 | |
| | NFCA CLASSIC |
| | 11 | 11:00AM | Brescia | vs. | Brevard College | 5-0 | |
| | NFCA CLASSIC |
| * | | 2:00PM | Berea | @ | Mid-Continent College | RAIN | |
| * | | Game 2 | Berea | @ | Mid-Continent College | RAIN | |
| | | 5:00PM | Brescia | vs. | Bellevue University | 2-0 | |
| | NFCA CLASSIC |
| | | 7:00PM | Brescia | vs. | Ohio Dominican College | 3-4 | (9) |
| | NFCA CLASSIC |
| * | 12 | 2:00PM | Berea | @ | Bethel College | 3-4 | |
| * | | Game 2 | Berea | @ | Bethel College | 0-10 | |
| | 13 | 4:00PM | Mid-Continent College | @ | Oakland City University | RAIN | |
| | | Game 2 | Mid-Continent College | @ | Oakland City University | RAIN | |
| * | 14 | 2:00PM | Bethel College | @ | Mid-Continent College | 3-13 | |
| * | | Game 2 | Bethel College | @ | Mid-Continent College | 3-5 | |
| | | 3:00PM | Brescia | vs. | Kentucky Wesleyan College | RAIN | |
| | | Game 2 | Brescia | vs. | Kentucky Wesleyan College | RAIN | |
| | 15 | 3:00PM | Avila College | @ | Mid-Continent College | 2-0 | |
| | | 5:00PM | Avila College | @ | Mid-Continent College | 2-0 | |
| | 16 | 3:00PM | Avila College | @ | Bethel College | 0-3 | |
| | | Game 2 | Avila College | @ | Bethel College | 1-7 | |
| | | 4:00PM | Brescia | @ | Union University | 1-6 | |
| | | Game 2 | Brescia | @ | Union University | 1-6 | |
| | 18 | 11:00AM | Berea | @ | Oakland City University | 2-3 | |
| | | Game 2 | Berea | @ | Oakland City University | 5-6 | |
| | | 3:00PM | Brescia | @ | Trevecca Nazarene University | 0-10 | |
| | | Game 2 | Brescia | @ | Trevecca Nazarene University | 5-6 | |
| * | | 3:00PM | Spalding University | @ | Mid-Continent College | 3-4 | |
| * | | Game 2 | Spalding University | @ | Mid-Continent College | 0-8 | |
| * | 19 | 2:00PM | Berea | @ | Brescia | 1-7 | |
| * | | Game 2 | Berea | @ | Brescia | 4-6 | |
| * | | 3:00PM | Spalding University | @ | Bethel College | 1-7 | |
| * | | Game 2 | Spalding University | @ | Bethel College | 6-14 | |
| | 20 | 6:00PM | Lindsey Wilson | @ | Midway | 18-3 | |
| | 22 | 2:00PM | Mid-Continent College | @ | Campbellsville University | RAIN | |
| | | Game 2 | Mid-Continent College | @ | Campbellsville University | RAIN | |
| | | 4:00PM | Brescia | @ | Lindsey Wilson | RAIN | |
| | | Game 2 | Brescia | @ | Lindsey Wilson | RAIN | |
| | | 4:30PM | Spalding University | @ | Bellarmine University | 1-9 | |
| * | 24 | 5:30PM | Alice Lloyd | @ | Berea | 1-16 | |
| * | | Game 2 | Alice Lloyd | @ | Berea | 0-15 | |
| * | | 6:00PM | Mid-Continent College | @ | Midway | 2-1 | |
| * | | Game 2 | Mid-Continent College | @ | Midway | 5-3 | |
| * | | 6:00PM | Brescia | @ | Spalding University | 8-1 | |
| * | | Game 2 | Brescia | @ | Spalding University | 8-6 | |
| * | 25 | 1:00PM | Mid-Continent College | @ | Berea | 2-1 | |
| * | | Game 2 | Mid-Continent College | @ | Berea | 9-7 | |
| * | | 3:00PM | Bethel College | @ | Midway | 5-1 | |
| * | | Game 2 | Bethel College | @ | Midway | 5-1 | |
| | 26 | 1:00PM | Oakland City University | @ | Spalding University | 7-8 | |
| * | | 1:00PM | Bethel College | @ | Alice Lloyd | RAIN | |
| * | | Game 2 | Bethel College | @ | Alice Lloyd | RAIN | |
| * | 27 | 1:00PM | Bethel College | @ | Alice Lloyd | 17-1 | |
| * | | Game 2 | Bethel College | @ | Alice Lloyd | 17-0 | |
| | | 3:00PM | Cumberland Univ. | @ | Mid-Continent College | 1-5 | |
| | | Game 2 | Cumberland Univ. | @ | Mid-Continent College | 8-2 | |
| | | 5:30PM | Oakland City University | @ | Berea | 6-7 | |
| | | Game 2 | Oakland City University | @ | Berea | 5-6 | |
| | 29 | 6:00PM | Lindsey Wilson | @ | Spalding University | 11-3 | |
| | At Ulmer Stadium- U of L Campus |
| | 30 | | Bethel College | @ | Trevecca Nazarene University | 8-12 | |
| | TNU Tied NAIA Record with 48th Home Run |
| | | 3:00PM | Bethel College | @ | Trevecca Nazarene University | 1-4 | |
| | Game 1 |
| | | 6:00PM | Mid-Continent College | @ | Union University | 0-5 | |
| | | Game 2 | Mid-Continent College | @ | Union University | 7-8 | (8) |
| * | 31 | 3:00PM | Brescia | @ | Bethel College | 0-6 | |
| * | | Game 2 | Brescia | @ | Bethel College | 0-12 | |
| April |
| | 1 | | Spalding University | @ | University of Illinois at Springfield | 9-6 | |
| | New Baden, IL |
| | | | Harris-Stowe State College | @ | Spalding University | 3-1 | |
| * | | 3:00PM | Brescia | @ | Mid-Continent College | 8-1 | |
| * | | Game 2 | Brescia | @ | Mid-Continent College | 2-0 | |
| | 3 | 5:00PM | Alice Lloyd | @ | Pikeville College | 1-11 | |
| * | 4 | 2:00PM | Mid-Continent College | @ | Bethel College | 2-10 | |
| | | 4:00PM | Brescia | @ | Southern Indiana | 1-8 | |
| | | Game 2 | Brescia | @ | Southern Indiana | 0-2 | |
| * | | Game 2 | Mid-Continent College | @ | Bethel College | 2-6 | |
| | 6 | 3:00PM | Freed-Hardeman | @ | Mid-Continent College | 1-2 | |
| | | Game 2 | Freed-Hardeman | @ | Mid-Continent College | 7-8 | (8) |
| | 7 | 2:00PM | Union University | @ | Brescia | 6-5 | |
| | | Game 2 | Union University | @ | Brescia | 12-0 | |
| * | | 3:00PM | Midway | @ | Mid-Continent College | 0-2 | |
| * | | Game 2 | Midway | @ | Mid-Continent College | 5-3 | |
| * | 8 | 12:00PM | Alice Lloyd | @ | Mid-Continent College | 0-1 | |
| * | | Game 2 | Alice Lloyd | @ | Mid-Continent College | 1-10 | |
| * | | 1:00PM | Midway | @ | Bethel College | RAIN | |
| * | | Game 2 | Midway | @ | Bethel College | RAIN | |
| * | 9 | 1:00PM | Alice Lloyd | @ | Bethel College | 0-24 | |
| * | | Game 2 | Alice Lloyd | @ | Bethel College | 0-7 | |
| | 11 | 3:00PM | Campbellsville University | @ | Mid-Continent College | 4-1 | |
| | | Game 2 | Campbellsville University | @ | Mid-Continent College | 7-0 | |
| * | | 6:00PM | Berea | @ | Alice Lloyd | 14-1 | |
| * | | Game 2 | Berea | @ | Alice Lloyd | 11-0 | |
| * | | 6:00PM | Brescia | @ | Midway | 14-2 | |
| * | | Game 2 | Brescia | @ | Midway | 14-2 | |
| | | 6:30PM | Spalding University | @ | Centre College | 5-6 | |
| * | 12 | 4:00PM | Bethel College | @ | Brescia | 16-0 | |
| * | | Game 2 | Bethel College | @ | Brescia | 3-4 | |
| | | 6:30PM | Spalding University | @ | Lindsey Wilson | 4-12 | |
| | 13 | 3:00PM | Mid-Continent College | @ | Cumberland Univ. | 6-1 | |
| | | Game 2 | Mid-Continent College | @ | Cumberland Univ. | 2-3 | |
| | 14 | 12:00PM | Brescia | @ | Oakland City University | 16-0 | |
| | | Game 2 | Brescia | @ | Oakland City University | 1-2 | |
| * | 15 | 1:00PM | Spalding University | @ | Alice Lloyd | 42-0 | (5) |
| * | | 2:00PM | Bethel College | @ | Berea | 9-4 | |
| * | | Game 2 | Bethel College | @ | Berea | 9-4 | |
| | 17 | 3:00PM | Union University | @ | Mid-Continent College | 2-4 | |
| | | Game 2 | Union University | @ | Mid-Continent College | 15-4 | |
| | 18 | 4:00PM | Bethel College | @ | Christian Brothers University | 7-5 | |
| | | Game 2 | Bethel College | @ | Christian Brothers University | 7-5 | |
| * | | 6:00PM | Midway | @ | Spalding University | 1-9 | (5) |
| * | 19 | 5:00PM | Mid-Continent College | @ | Brescia | 1-2 | |
| * | | Game 2 | Mid-Continent College | @ | Brescia | 5-6 | |
| | 20 | | Pikeville College | @ | Alice Lloyd | 21-1 | |
| | Make-up from 3/22/06 |
| | 21 | 4:30PM | St. Mary of the Woods | @ | Brescia | RAIN | |
| | | Game 2 | St. Mary of the Woods | @ | Brescia | RAIN | |
| | 22 | | Mid-Continent College | @ | Oakland City University | 1-2 | |
| | NCCAA Regional Tournament |
| | | | Mid-Continent College | @ | Oakland City University | 2-5 | |
| | NCCAA Regional Tournament |
| | | Game 2 | Mid-Continent College | @ | Oakland City University | 2-5 | |
| | | 2:00PM | Bethel College | @ | Martin Methodist | 7-5 | |
| | | Game 2 | Bethel College | @ | Martin Methodist | 7-5 | |
| * | | 2:00PM | Brescia | @ | Berea | RAIN | |
| * | | Game 2 | Brescia | @ | Berea | RAIN | |
| | | Game 2 | Bethel College | @ | Martin Methodist | 7-5 | |
| * | 23 | 1:00PM | Brescia | @ | Alice Lloyd | 20-0 | |
| * | | Game 2 | Brescia | @ | Alice Lloyd | 20-0 | |
| | | 3:00PM | Lambuth University | @ | Bethel College | 1-8 | |
| | | Game 2 | Lambuth University | @ | Bethel College | 0-3 | |
| * | 24 | 6:00PM | Spalding University | @ | Midway | 7-3 | |
| * | 25 | 5:30PM | Spalding University | @ | Berea | 8-2 | |
| * | | Game 2 | Spalding University | @ | Berea | 8-2 | |
| * | 26 | 6:00PM | Berea | @ | Midway | 6-0 | |
| * | | 8:00PM | Berea | @ | Midway | 6-4 | |
| * | 27 | 5:30PM | Midway | @ | Berea | 1-2 | |
| * | | 7:30PM | Midway | @ | Berea | 0-5 | |
| * | 28 | 6:00PM | Spalding University | @ | Brescia | 4-8 | |
| * | | Game 2 | Spalding University | @ | Brescia | 10-1 | |
| | 29 | 2:00PM | Berea | @ | Union College | 5-10 | |
| | | Game 2 | Berea | @ | Union College | 10-6 | |
| * | | 3:00PM | Midway | @ | Brescia | 1-14 | |
| * | | Game 2 | Midway | @ | Brescia | 1-5 | |
| * | 30 | 1:00PM | Alice Lloyd | @ | Brescia | 0-18 | |
| * | | Game 2 | Alice Lloyd | @ | Brescia | 0-18 | |
| May |
| * | 2 | 7:00PM | Mid-Continent College | @ | Spalding University | 6-0 | |
| | Ulmer Stadium- U of L Campus |
| | | Game 2 | Mid-Continent College | @ | Spalding University | 2-5 | |
| | 4 | | Spalding University | vs. | Berea | 6-7 | |
| | KIAC CONF TOURNEY |
| | | 10:00AM | Berea | vs. | Spalding University | 7-6 | |
| | KIAC Tournament Day One |
| | | 10:00AM | Mid-Continent College | vs. | Midway | 8-0 | |
| | KIAC Tournament Day One |
| | | 10:00AM | Alice Lloyd | vs. | Brescia | 0-18 | |
| | KIAC Tournament Day One |
| | | 12:00PM | Bethel College | vs. | Berea | 5-7 | |
| | KIAC Tournament Day One |
| | | 12:00PM | Mid-Continent College | vs. | Brescia | 5-3 | |
| | KIAC Tournament Day One |
| | | 12:00PM | Midway | vs. | Alice Lloyd | 10-3 | |
| | KIAC Tournament Day One-ALC Eliminated |
| | | 2:00PM | Brescia | vs. | Spalding University | 11-5 | |
| | KIAC Tournament Day One-Spalding Eliminated |
| | | 2:00PM | Bethel College | vs. | Midway | 8-0 | |
| | KIAC Tournament Day One-Midway Eliminated |
| | | 4:00PM | Berea | vs. | Mid-Continent College | 3-5 | |
| | KIAC Tournament Day One |
| | | 4:00PM | Brescia | vs. | Bethel College | 4-3 | |
| | KIAC Tournament Day One-Bethel Eliminated |
| | 5 | | Spalding University | vs. | Brescia | 5-11 | |
| | KIAC CONF. TOURNEY |
| | | 9:00AM | Berea | vs. | Brescia | 2-10 | |
| | KIAC Tournament Day Two-Berea Eliminated |
| | | 11:00AM | Mid-Continent College | vs. | Brescia | 7-5 | |
| | KIAC Tournament Championship Game |
| | 11 | | Bethel College | vs. | Mid-Continent College | 3-1 | |
| | 2006 NAIA Region XII Tournament, Owensboro, Ky. |
| | | | Bethel College | vs. | UVA-Wise | 8-6 | (9) |
| | NAIA Region XII Tournament, Owensboro, Ky. Winner's Bracket Finals |
| | 12 | 2:00PM | Bethel College | vs. | Tennessee Wesleyan | 7-6 | |
| | 2006 NAIA Region XII Championship, Owensboro, Ky. Bethel advances to NAIA Softball National Championships |
| | 19 | 11:30AM | Bethel College | vs. | Simon Fraser University | 0-15 | |
| | NAIA National Tournament, Pool D Play |
| | | 7:00PM | Bethel College | vs. | Saint Gregory's University | 2-1 | |
| | NAIA National Tournament, Pool D Play |
| | 20 | 2:00PM | Bethel College | vs. | Valley City State University | 2-4 | |
| | NAIA National Tournament, Pool D Play |
| | | 9:30PM | Bethel College | vs. | Trevecca Nazarene University | 0-5 | |
| | NAIA National Championship, Decatur, Ala. |
